Ferredoxin—nitrite reductase
| ferredoxin—nitrite reductase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| EC number | 1.7.7.1 | ||||||
| CAS number | 37256-44-3 | ||||||
| Databases | |||||||
| IntEnz | IntEnz view | ||||||
| BRENDA | BRENDA entry | ||||||
| ExPASy | NiceZyme view | ||||||
| KEGG | KEGG entry | ||||||
| MetaCyc | metabolic pathway | ||||||
| PRIAM | profile | ||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||
| Gene Ontology | AmiGO / EGO | ||||||
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In enzymology, a ferredoxin—nitrite reductase (EC 1.7.7.1) is an enzyme that catalyzes the chemical reaction
- NH3 + 2 H2O + 6 oxidized ferredoxin
nitrite + 6 reduced ferredoxin + 7 H+
The 3 substrates of this enzyme are NH3, H2O, and oxidized ferredoxin, whereas its 3 products are nitrite, reduced ferredoxin, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with an iron-sulfur protein as acceptor. The systematic name of this enzyme class is ammonia:ferredoxin oxidoreductase. This enzyme participates in nitrogen metabolism. It has 3 cofactors: iron, Siroheme, and Iron-sulfur.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1ZJ8, 1ZJ9, and 2AKJ.
References
- Joy KW, Hageman RH (1966). "The purification and properties of nitrite reductase from higher plants, and its dependence on ferredoxin". Biochem. J. 100 (1): 263–73. PMC 1265119. PMID 4381617. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1265119.
- Ramirez JM, Del Campo FF, Paneque A, Losada M (1966). "Ferredoxin-nitrite reductase from spinach". Biochim. Biophys. Acta. 118 (1): 58–71. PMID 5954064.
- Zumft WG, Paneque A, Aparicio PJ, Losada M (1969). "Mechanism of nitrate reduction in Chlorella". Biochem. Biophys. Res. Commun. 36 (6): 980–6. doi:10.1016/0006-291X(69)90300-3. PMID 4390523.